electroceuticals

Understanding how electrical stimulation can be optimized as a medical therapeutic

Description

There is considerable interest in leveraging electrical stimulation as a medical therapeutic. This has led to an interest in “electroceutical” therapies. While there has been a lot of success and FDA-approved devices (including deep brain stimulation for Parkinson’s disease, vagus nerve stimulation for epilepsy, retinal ganglion stimulation for retinopathy), the underlying mechanisms are not fully understood. Much of the focus today is on the use of rectangular waveforms, but our lab hypothesizes that non-traditional, customized waveforms can produce more energetically-efficient and selective stimulation. We are working on developing novel algorithms to find these more efficient waveform, as well as discovering the mechanisms underlying how these non-traditional waveforms are unlocking different access mechanisms for selective stimulation.

Relevant Publications

  1. Chaos
    Chang, Joshua,  and Paydarfar, David
    Chaos: An Interdisciplinary Journal of Nonlinear Science 2021
  2. Methods for Optimizing Stimulus Waveforms for Electroceutical Control
    Chang, Joshua,  and Paydarfar, David
    Encyclopedia of Computational Neuroscience 2020
  3. Chaos
    Chang, Joshua, Sridhar, Varun,  and Paydarfar, David
    Chaos: An Interdisciplinary Journal of Nonlinear Science 2020
  4. BioCyb
    Chang, Joshua,  and Paydarfar, David
    Biological Cybernetics 2019
  5. SciRep
    Chang, Joshua,  and Paydarfar, David
    Scientific Reports 2018
  6. IEEE
    Chang, Joshua,  and Paydarfar, David
    In 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2018
  7. IEEE
    Chang, Joshua,  and Paydarfar, David
    In 2015 7th International IEEE/EMBS Conference on Neural Engineering (NER) 2015
  8. JCN
    Chang, Joshua,  and David, Paydarfar
    Journal of Computational Neuroscience 2014

Relevant Repositories

Funding

Clayton Foundation for Research